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Harnessing mosquitoes for epidemic and pandemic research in Africa

Africa Pandemic sciences, banner. TGHN
  • CLEAR-Africa
  • Harnessing mosquitoes for epidemic … rch in Africa
  • ACCEPT-Africa
  • Strengthening Clinical and Genomics … Arboviruses
  • SHARPER
  • PREPARE
  • SPIL-OVA

Harnessing mosquitoes for epidemic and pandemic research in Africa

 

Harnessing mosquitoes for epidemic and pandemic research in Africa


Research area
Climate change, biodiversity and pandemic prevention

Lead Institution
Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso (Professor Abdoulaye Diabate)

Partners

  • Malaria Research & Training Center, Mali (Dr Adama Dao)
  • Sya Innovation Center (SIC), Burkina Faso (Dr Léa Paré Toé)
  • Noguchi Memorial Institute for Medical Research, Ghana (Professor Samuel Kweku Dadzie)
  • National Institute of Allergy and Infectious Diseases (NIH), USA (Dr Tovi Lehmann)
  • Max Planck Institute for Infection Biology, Germany (Dr Silvia Portugal)

Project
Harnessing mosquitoes for epidemic and pandemic research in Africa


Human-made environmental changes across Africa erode biodiversity and disrupt ecosystems, with impacts on the spread of zoonotic disease with epidemic potential. This project will use mosquitoes as natural “samplers” of vertebrates to monitor changes in pathogen diversity and transmission dynamics.

Using advanced diagnostic technologies in serology and metagenomics, the programme will analyse mosquito bloodmeals from humans and animals to detect prior exposure to 20 epidemic-prone pathogens; assess changes in exposure risk along “urban–rural–forest” transects; and collect windborne mosquitoes at high altitude, as well as on the ground, to identify their role in spreading arboviruses over long distances.

Monitoring changes in the species composition of mosquitoes, vertebrate hosts, and pathogens, this work will analyse the effect of human-made environmental changes, bolster early-warning systems, and inform prevention and mitigation strategies. The programme will also generate baselines for assessing future changes and address knowledge gaps such as identifying pathogen reservoirs.

Harnessing mosquitoes for epidemic and pandemic research in Africa


Domaine de recherche
Climate change, biodiversity and pandemic prevention

Institution chef de file
Institut de Recherche en Sciences de la Santé (IRSS), Burkina Faso (Professor Abdoulaye Diabate)

Partenaires

  • Malaria Research & Training Center, Mali (Dr Adama Dao)
  • Sya Innovation Center (SIC), Burkina Faso (Dr Léa Paré Toé)
  • Noguchi Memorial Institute for Medical Research, Ghana (Professor Samuel Kweku Dadzie)
  • National Institute of Allergy and Infectious Diseases (NIH), USA (Dr Tovi Lehmann)
  • Max Planck Institute for Infection Biology, Germany (Dr Silvia Portugal)

Projet
Harnessing mosquitoes for epidemic and pandemic research in Africa


Les changements environnementaux d’origine humaine à travers l’Afrique érodent la biodiversité et perturbent les écosystèmes, avec des répercussions sur la propagation des maladies zoonotiques à potentiel épidémique. Ce projet utilisera les moustiques comme « échantillonneurs » naturels de vertébrés afin de suivre l’évolution de la diversité des agents pathogènes et des dynamiques de transmission.

En recourant à des technologies diagnostiques avancées (sérologie, métagénomique), le programme analysera les repas sanguins des moustiques provenant d’humains et d’animaux pour détecter leur exposition antérieure à 20 agents pathogènes à potentiel épidémique ; évaluer les variations du risque d’exposition le long de transects « urbain–rural–forêt » ; et collecter des moustiques transportés par le vent à haute altitude, ainsi qu’au sol, afin d’évaluer leur rôle dans la dissémination des arbovirus sur de longues distances.

En surveillant les changements dans la composition des espèces de moustiques, des hôtes vertébrés et des agents pathogènes, ce travail analysera les effets des modifications d’origine humaine, renforcera les systèmes d’alerte précoce et éclairera les stratégies de prévention et d’atténuation. Le programme produira également des données de référence (baselines) pour suivre les évolutions futures et combler des lacunes de connaissances, notamment en identifiant les réservoirs de pathogènes.

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